BDBM50513230 CHEMBL4456471

SMILES CN1CCC(CC1)Nc1ccc(cc1)C(=O)Nc1cc(n[nH]1)-c1ccc2OCOc2c1

InChI Key InChIKey=OKFAZZUSWJWRJN-UHFFFAOYSA-N

Data  19 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50513230   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of human FLT3 R595_E596insEY mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human FLT3-ITD mutant preincubated with enzyme for 20 mins followed by [gamma-33P]ATP addition and measured after 120 mins by filter bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNT-3 growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 33nMAssay Description:Inhibition of TRKC (unknown origin) in presence of [gamma33P]ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 805nMAssay Description:Inhibition of TRKB (unknown origin) in presence of [gamma33P]ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 432nMAssay Description:Inhibition of TRKA (unknown origin) in presence of [gamma33P]ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 18nMAssay Description:Inhibition of human FLT3 Y591_V592insVDFREYEYD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 18nMAssay Description:Inhibition of human FLT3 ITD/W51 double mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataKd:  90nMAssay Description:Inhibition of human FLT3 ITD/F691L double mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 24nMAssay Description:Inhibition of human FLT3 ITD/NPOS double mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 67nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of human ABL1 using EAIYAAPFAKKK as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 247nMAssay Description:Inhibition of human FMS using poly(Glu,Tyr) 4:1 as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 432nMAssay Description:Inhibition of human TRKA using poly(Glu,Tyr) 4:1 as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataKd:  160nMAssay Description:Inhibition of human FLT3 ITD/D835V double mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 10nMAssay Description:Inhibition of human FLT3 F594_R595insREY mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 11nMAssay Description:Inhibition of human FLT3 F594_R595insR mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 19nMAssay Description:Inhibition of human FLT3 D835Y mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 860nMAssay Description:Inhibition of human LCK using poly(Glu,Tyr) 4:1 as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 616nMAssay Description:Inhibition of human C-kit using poly(Glu,Tyr) 4:1 as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 161nMAssay Description:Inhibition of human BTK using poly(Glu,Tyr) 4:1 as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50513230(CHEMBL4456471)
Affinity DataKd:  7.30nMAssay Description:Inhibition of human FLT3 D835V mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed