BDBM50513570 CHEMBL4523063

SMILES COc1cc(ccc1Nc1cc(ccn1)N1CCC[C@@H](C1)C(=O)NCc1ccc(OC(F)(F)F)cc1)N1CCNCC1

InChI Key InChIKey=JQWJRFOFKDLCQB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50513570   

TargetALK tyrosine kinase receptor(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50513570(CHEMBL4523063)
Affinity DataIC50: 41nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin) at 1 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50513570(CHEMBL4523063)
Affinity DataIC50: 174nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK (catalytic domain 1058 - 1620 residues) expressed in baculovirus system assessed as decreas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50513570(CHEMBL4523063)
Affinity DataIC50: 530nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ROS1 (catalytic domain 1883 - 2347 residues) expressed in baculovirus system assessed as decrea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed