BDBM50513626 CHEMBL4473502

SMILES CCc1c(cccc1C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F)C#Cc1cnc2cnccn12

InChI Key InChIKey=KSVGVUZJQAEMMJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50513626   

TargetNT-3 growth factor receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50513626(CHEMBL4473502)
Affinity DataIC50: 129nMAssay Description:Inhibition of recombinant human His-tagged TrkC cytoplasmic domain (510 to 825 residues) expressed in baculovirus using tyr 01 as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50513626(CHEMBL4473502)
Affinity DataIC50: 186nMAssay Description:Inhibition of recombinant human His-tagged TrkA catalytic domain (441 to 796 residues) expressed in baculovirus expression system using tyr 01 as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50513626(CHEMBL4473502)
Affinity DataIC50: 315nMAssay Description:Inhibition of recombinant human His-tagged TrkB catalytic domain (526 to 838 residues) expressed in baculovirus expression system using tyr 01 as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50513626(CHEMBL4473502)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant full length human His-tagged ABL1 expressed in baculovirus infected insect cells using tyr 02 as substrate incubated for 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed