BDBM50514044 CHEMBL4588734

SMILES [H][C@@]12C[C@H](CC(O)=O)CN1C(=O)[C@]1([H])Cc3c(n(C(=O)OC(C)(C)C)c4ccccc34)[C@@]2([H])N1C(=O)CC1CCC(F)(F)CC1

InChI Key

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50514044   

TargetGlucagon-like peptide 1 receptor(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50514044(CHEMBL4588734)
Affinity DataEC50:  5nMAssay Description:Positive allosteric modulator activity at human GLP-1R expressed in PSC-HEK293 cells in presence of EC20 level of GLP1(9-36)NH2 incubated for 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50514044(CHEMBL4588734)
Affinity DataEC50:  130nMAssay Description:Positive allosteric modulator activity at GLP-1R in human 1.1B4 cells in presence of EC20 level of GLP1(9-36)NH2 incubated for 30 mins by HTRF cAMP a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50514044(CHEMBL4588734)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50514044(CHEMBL4588734)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50514044(CHEMBL4588734)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed