BDBM50514115 CHEMBL4447716

SMILES Cc1ccc(-c2[nH]c3ncccc3c2CCC(=O)N2CCOC[C@H]2c2nc3ccccc3[nH]2)c(-c2ccccc2)c1

InChI Key InChIKey=NWWYHKMOCXEJLJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50514115   

TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514115BDBM50514115(CHEMBL4447716)
Affinity DataIC50: 60nMAssay Description:Inhibition of CSN5 (unknown origin) using fluorescence-labeled CRL substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514115BDBM50514115(CHEMBL4447716)
Affinity DataIC50: 90nMAssay Description:Inhibition of CSN5 (unknown origin) using PT22-Nedd8-Cul4A as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514115BDBM50514115(CHEMBL4447716)
Affinity DataIC50: 840nMAssay Description:Inhibition of CSN5 (2 to 257 residues) (unknown origin) expressed in transetta cells preincubated for 20 mins followed by probe addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed