BDBM50514141 CHEMBL4543348

SMILES [O-][N+](=O)c1c(I)cccc1Oc1ccc(cc1)-c1nnco1

InChI Key InChIKey=WDSXFPOBWVVWRC-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50514141   

TargetToll-like receptor 8(Human)
University of Colorado Boulder

Curated by ChEMBL
LigandPNGBDBM50514141(CHEMBL4543348)
Affinity DataKd:  86nMAssay Description:Binding affinity to human TLR8 (27 to 827 residues) expressed in HEK293 cells in presence of R848 by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
University of Colorado Boulder

Curated by ChEMBL
LigandPNGBDBM50514141(CHEMBL4543348)
Affinity DataIC50: 300nMAssay Description:Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
University of Colorado Boulder

Curated by ChEMBL
LigandPNGBDBM50514141(CHEMBL4543348)
Affinity DataIC50: 620nMAssay Description:Inhibition of human TLR8 expressed in HEK293 cells assessed as reduction in ssRNA-induced NFkappaB production incubated for 16 hrs by quanti-blue SEA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado Boulder

Curated by ChEMBL
LigandPNGBDBM50514141(CHEMBL4543348)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human TLR7 expressed in HEK293 cells assessed as reduction in R848-induced NFkappaB production incubated for 16 hrs by quanti-blue SEAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed