BDBM50514671 CHEMBL4532803

SMILES [H][C@]12CCC=C(C(O)=O)[C@]1(C)[C@@H](O)C[C@@H](C)[C@]2(C)CCc1ccoc1

InChI Key InChIKey=XWKYXEIGWQYOCY-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50514671   

TargetEndoplasmic reticulum aminopeptidase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514671(CHEMBL4532803)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full length C-terminal His6-tagged ERAP1 (unknown origin)-mediated antigenic epitope destruction assessed as inhibition of trimming of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-1 receptor antagonist protein(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514671(CHEMBL4532803)
Affinity DataIC50: 2.51E+5nMAssay Description:Activation of IRAP (unknown origin)-mediated Leu-AMC substrate hydrolysis after 60 mins by Rapidfire-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetEndoplasmic reticulum aminopeptidase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514671(CHEMBL4532803)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of full length C-terminal His6-tagged ERAP1 (unknown origin)-mediated chicken ovalbumin antigenic epitope processing assessed as reduction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514671(CHEMBL4532803)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of ERAP1-mediated antigen epitope presentation in human HeLa cells transfected with Bacmam virus containing mouse MHC-1 allele H-2 Kb, bet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514671(CHEMBL4532803)
Affinity DataIC50: 1.58E+5nMAssay Description:Activation of ERAP2 (unknown origin)-mediated Arg-AMC substrate hydrolysis after 60 mins by Rapidfire-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetEndoplasmic reticulum aminopeptidase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514671(CHEMBL4532803)
Affinity DataIC50: 1.00E+3nMAssay Description:Activation of full length C-terminal His6-tagged ERAP1 (unknown origin)-mediated fluorogenic Leu-AMC substrate hydrolysis after 60 mins by Rapidfire-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndoplasmic reticulum aminopeptidase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514671(CHEMBL4532803)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of full length C-terminal His6-tagged ERAP1 (unknown origin)-mediated chicken ovalbumin antigenic epitope processing assessed as reduction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)