BDBM50515229 CHEMBL4577779
SMILES COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2cc1OC
InChI Key InChIKey=YOHLRCOPRAVUCJ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 34 hits for monomerid = 50515229
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R cells assessed as reduction in c-KIT autophosphorylation at Y719 residue measure...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in AKT phosphorylation at S473 residue measured afte...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in pS6 phosphorylation at S236 residue measured afte...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R assessed as reduction in AKT phosphorylation at T308 residue measured after 2 hr...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R assessed as reduction in AKT phosphorylation at S473 residue measured after 2 hr...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R assessed as reduction in pS6 phosphorylation at S235 residue measured after 2 hr...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R assessed as reduction in ERK phosphorylation at T202 residue measured after 2 hr...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R cells assessed as reduction in c-KIT autophosphorylation at Y703 residue measure...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in ERK phosphorylation at T202 residue measured afte...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in ERK phosphorylation at T204 residue measured after 2 hr...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in pS6 phosphorylation at S235 residue measured after 2 hr...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in AKT phosphorylation at T308 residue measured afte...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in ERK phosphorylation at T204 residue measured afte...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R assessed as reduction in pS6 phosphorylation at S236 residue measured after 2 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human KITMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Human)
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human GST-tagged PDGFRA cytoplasmic domain (550 to 1089 residues) expressed in baculovirus expression system by Z-lyte assa...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in c-KIT autophosphorylation at Y823 residue measured afte...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in c-KIT autophosphorylation at Y719 residue measured afte...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in pS6 phosphorylation at S235 residue measured afte...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R assessed as reduction in ERK phosphorylation at T204 residue measured after 2 hr...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in c-KIT autophosphorylation at Y703 residue measured afte...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in AKT phosphorylation at T308 residue measured after 2 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of human N-terminal GST-tagged KIT V559D/T670I double mutant (544 to end residues) expressed in baculovirus infected Sf9 insect cells by L...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus expression system by Z-lyte assayMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Human)
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 97nMAssay Description:Inhibition of recombinant human His-tagged PDGFRB cytoplasmic domain (558 to 1106 residues) expressed in baculovirus expression system by Z-lyte assa...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of recombinant human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus expression system by Z-lyte assayMore data for this Ligand-Target Pair
TargetEpithelial discoidin domain-containing receptor 1(Human)
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 135nMAssay Description:Inhibition of human GST-tagged DDR1 catalytic domain (440 to 876 residues) expressed in baculovirus expression system by Lanthascreen Eu-binding assa...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in c-KIT autophosphorylation at Y703 residue measure...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in c-KIT autophosphorylation at Y719 residue measure...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GISTT1 cells assessed as reduction in c-KIT autophosphorylation at Y823 residue measure...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion/T670I mutant in human GIST5R cells assessed as reduction in c-KIT autophosphorylation at Y823 residue measure...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in AKT phosphorylation at S473 residue measured after 2 hr...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in pS6 phosphorylation at S236 residue measured after 2 hr...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Inhibition of c-KIT 560 to 578 deletion mutant in human GISTT1 cells assessed as reduction in ERK phosphorylation at T202 residue measured after 2 hr...More data for this Ligand-Target Pair