BDBM50515428 CHEMBL4554795

SMILES COc1nc(N[C@H]2CC[C@H](N)CC2)c(F)cc1C(N)=O

InChI Key InChIKey=IMZIJLMIOSQRGE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50515428   

TargetRho-associated protein kinase 2(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50515428(CHEMBL4554795)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of recombinant human GST-tagged ROCK2 (1 to 552 residues) using myelin basic protein as substrate incubated for 30 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50515428(CHEMBL4554795)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human GST-tagged ROCK1 (1 to 535 residues) using myelin basic protein as substrate incubated for 30 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed