BDBM50515746 CHEMBL4445433

SMILES Cc1ccc(C)c(c1)S(=O)(=O)N1CCN(Cn2cc3c(n2)c2ccccc2oc3=O)CC1

InChI Key InChIKey=YJTWTJDYYWKDQV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50515746   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
School of Traditional Chinese Pharmacy

Curated by ChEMBL
LigandPNGBDBM50515746(CHEMBL4445433)
Affinity DataIC50: 810nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using diC8-PI(4,5)P2 as substrate incubated for 3 hrs in presence of ATP by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
School of Traditional Chinese Pharmacy

Curated by ChEMBL
LigandPNGBDBM50515746(CHEMBL4445433)
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using diC8-PI(4,5)P2 as substrate incubated for 3 hrs in presence of ATP by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
School of Traditional Chinese Pharmacy

Curated by ChEMBL
LigandPNGBDBM50515746(CHEMBL4445433)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
School of Traditional Chinese Pharmacy

Curated by ChEMBL
LigandPNGBDBM50515746(CHEMBL4445433)
Affinity DataIC50: 300nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using diC8-PI(4,5)P2 as substrate incubated for 3 hrs in presence of ATP by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
School of Traditional Chinese Pharmacy

Curated by ChEMBL
LigandPNGBDBM50515746(CHEMBL4445433)
Affinity DataIC50: 850nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using diC8-PI(4,5)P2 as substrate incubated for 3 hrs in presence of ATP by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed