BDBM50516025 CHEMBL4475248

SMILES CC(F)(F)CN1C(=O)[C@]2(C)COCCN2c2nc(ncc12)-c1ccc(NC(=O)NC2CC2)cc1

InChI Key InChIKey=TVISMJDQTRLBBY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50516025   

TargetSerine/threonine-protein kinase mTOR(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50516025(CHEMBL4475248)
Affinity DataIC50: 13nMAssay Description:Inhibition of human mTOR measured after 30 mins in presence of ATP by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM50516025(CHEMBL4475248)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of PI3K alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50516025(CHEMBL4475248)
Affinity DataIC50: 70nMAssay Description:Inhibition of TORC2 in human PC-3 cells assessed as reduction in Akt phosphorylation at Ser473 residueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50516025(CHEMBL4475248)
Affinity DataIC50: 49nMAssay Description:Inhibition of TORC1 in human PC-3 cells assessed as reduction in S6K phosphorylation at T389 residueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed