BDBM50516225 CHEMBL4521524

SMILES Cc1ccc(cc1)S(=O)(=O)N[C@@H](CC(=O)NC(C)(C)C)C(=O)NCCNC(=O)c1cc(ccc1F)-c1ccccc1F

InChI Key InChIKey=SAQXBNSPOWSONB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50516225   

TargetProteasome subunit beta type-8(Human)
Weill Cornell Medicine

Curated by ChEMBL
LigandPNGBDBM50516225(CHEMBL4521524)
Affinity DataIC50: 4nMAssay Description:Inhibition of human beta5 20S immunoproteasome using Ac-ANW-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Weill Cornell Medicine

Curated by ChEMBL
LigandPNGBDBM50516225(CHEMBL4521524)
Affinity DataIC50: 110nMAssay Description:Inhibition of human beta5 20S constitutive proteasome using suc-LLVY-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Weill Cornell Medicine

Curated by ChEMBL
LigandPNGBDBM50516225(CHEMBL4521524)
Affinity DataIC50: 4nMAssay Description:Inhibition of 20S proteasome beta 5i (unknown origin) after 1 hr by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Weill Cornell Medicine

Curated by ChEMBL
LigandPNGBDBM50516225(CHEMBL4521524)
Affinity DataIC50: 110nMAssay Description:Inhibition of 20S proteasome beta 5c (unknown origin) after 1 hr by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Weill Cornell Medicine

Curated by ChEMBL
LigandPNGBDBM50516225(CHEMBL4521524)
Affinity DataIC50: 110nMAssay Description:Inhibition of human 20s constitutive proteasome beta-5cMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Weill Cornell Medicine

Curated by ChEMBL
LigandPNGBDBM50516225(CHEMBL4521524)
Affinity DataIC50: 4nMAssay Description:Inhibition of human 20s immunoproteasome beta-5i subunitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed