BDBM50516389 CHEMBL4527483

SMILES Fc1cccc(Br)c1C(=O)c1c[nH]c(c1)C(=O)Nc1ccncc1

InChI Key InChIKey=CCFJADOHYLGZML-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50516389   

TargetMitogen-activated protein kinase 7(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516389(CHEMBL4527483)
Affinity DataIC50: 700nMAssay Description:Inhibition of recombinant N-terminal His-tagged human ERK5 (2 to 409 residues) co-expressed with GST-tagged human truncated MEK5DD lacking N-terminal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516389(CHEMBL4527483)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of recombinant N-terminal GST-tagged full length human p38alpha expressed in Escherichia coli cells assessed as substrate phosphorylation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516389(CHEMBL4527483)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of HA-tagged ERK5 (unknown origin) coexpressed with mutationally activated EGFP-MEK5D and Gal4-MEF2D in HEK293 cells assessed as reduction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed