BDBM50517156 CHEMBL4559894

SMILES Cc1nnn(C2CCN(CC2)C(N)=N)c1-c1cccc(Oc2cc(C)cc(C)c2)n1

InChI Key InChIKey=LTVHUTQVMLLORB-UHFFFAOYSA-N

Data  2 IC50  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50517156   

TargetBromodomain-containing protein 4(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517156(CHEMBL4559894)
Affinity DataKd:  940nMAssay Description:Binding affinity to human partial length BRD4 bromodomain 2 long isoform (K333 to E460 residues) expressed in bacterial expression system by BROMOsca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517156(CHEMBL4559894)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to human partial length BRD4 bromodomain 1 long isoform (N44 to E168 residues) expressed in bacterial expression system by BROMOscan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517156(CHEMBL4559894)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of biotinylated histone H4 peptide binding to BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) after 60 mins by Alphascreen methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517156(CHEMBL4559894)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of BRD4 bromodomain 1 (unknown origin) expressed in Escherichia coli Bl21(DE3)-pRARE cells by fluorescence anisotropyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517156(CHEMBL4559894)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517156(CHEMBL4559894)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to human partial length SMARCA2 (S1377 to Q1486 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517156(CHEMBL4559894)
Affinity DataKd: >2.00E+5nMAssay Description:Binding affinity to wild-type human full length p38-alpha (M1 to S360 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed