BDBM50517497 CHEMBL4593911

SMILES O=C(CN1CCOCC1)Nc1ccc(OC2CCN(CC2)C2CCC2)cc1

InChI Key InChIKey=LNXDUSQEXVQFGP-UHFFFAOYSA-N

Data  2 KI  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50517497   

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50517497(CHEMBL4593911)
Affinity DataKi:  8.70nMAssay Description:Displacement of [3]-RAMH from recombinant human histamine H3 receptor expressed in CHO-K1 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50517497(CHEMBL4593911)
Affinity DataKi:  9.80nMAssay Description:Displacement of [3]-RAMH from rat histamine H3 receptor expressed in CHO-K1 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50517497(CHEMBL4593911)
Affinity DataIC50: 20nMAssay Description:Inverse agonist activity at recombinant human Histamine 3 receptor expressed in CHO-K1 cells assessed as inhibition of RAMH-induced agonist activity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50517497(CHEMBL4593911)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2E1(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50517497(CHEMBL4593911)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2E1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50517497(CHEMBL4593911)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 2 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50517497(CHEMBL4593911)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50517497(CHEMBL4593911)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 12 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50517497(CHEMBL4593911)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50517497(CHEMBL4593911)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50517497(CHEMBL4593911)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50517497(CHEMBL4593911)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of CYP2A6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50517497(CHEMBL4593911)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed