BDBM50517575 CHEMBL4473451

SMILES ONC(=O)c1ccc(CN2c3ccccc3[S+]([O-])c3ccccc23)cc1

InChI Key InChIKey=PXJSYQWAMWAEEN-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50517575   

TargetHistone deacetylase 6(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50517575(CHEMBL4473451)
Affinity DataIC50: 21nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus-infected Sf9 cells using Boc-Lys (acetyl)-AMC as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50517575(CHEMBL4473451)
Affinity DataIC50: 77nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human HDAC6 expressed in baculovirus expression system using fluorogenic ZMAL as substrate incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50517575(CHEMBL4473451)
Affinity DataIC50: 2.76E+3nMAssay Description:Inhibition of HDAC in human HeLa nuclear extracts using Boc-Lys (acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50517575(CHEMBL4473451)
Affinity DataIC50: 5.15E+3nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC7 (518 to end residues) expressed in baculovirus-infected Sf9 cells using Boc Lys(TFA)-AMC as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50517575(CHEMBL4473451)
Affinity DataIC50: 6.62E+3nMAssay Description:Inhibition of N-terminal GST-tagged and C-terminal His-tagged human HDAC4 (627 to 1084 residues) expressed in baculovirus infected Sf9 cells using Bo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Ludwig-Maximilians University Munich

Curated by ChEMBL
LigandPNGBDBM50517575(CHEMBL4473451)
Affinity DataIC50: 6.81E+3nMAssay Description:Inhibition of recombinant C-terminal His/FLAG-tagged human HDAC1 expressed in baculovirus expression system using fluorogenic ZMAL as substrate incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50517575(CHEMBL4473451)
Affinity DataIC50: 2.76E+4nMAssay Description:Inhibition of C-terminal His-tagged human HDAC9 (604 to 1066 residues) expressed in baculovirus-infected Sf9 cells using Boc Lys(TFA)-AMC as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed