BDBM50517590 CHEMBL4454637

SMILES COc1ccc2C(N(CCc2n1)C(C)=O)C(=O)Nc1ccc(OCc2ccccc2Cl)cc1

InChI Key InChIKey=SBLXUTDYBJYLLL-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50517590   

TargetNuclear receptor ROR-gamma(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50517590(CHEMBL4454637)
Affinity DataIC50: 290nMAssay Description:Displacement of BODIPY-labeled-5-((2Z)-2-((1-(difluoroboryl)-3,5-dimethyl-1H-pyrrol-2-yl)-methylene)-2H-pyrrol-5-yl)-N-(2-((3,5-difluoro-4-(trimethyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50517590(CHEMBL4454637)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at His-tagged human RORgammaT assessed as induction of biotinylated SRC-1 peptide recruitment after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50517590(CHEMBL4454637)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at RORgammaT (unknown origin) expressed in human Jurkat cells co-expressing human IL-17 ROR response element by luciferase reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed