BDBM50517657 CHEMBL4592349

SMILES C[S+]([O-])c1ncccc1CNc1ncc(C#N)c(NCC23CC4CC(C2)C(NC[C@H]2CC[C@H](O)CC2)C(C4)C3)n1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50517657   

TargetProtein kinase C theta type(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50517657(CHEMBL4592349)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human full length PKCtheta using biotin-labelled STK substrate-1 as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50517657(CHEMBL4592349)
Affinity DataIC50: 170nMAssay Description:Inhibition of PKCtheta in human Jurkat cells assessed as reduction in IL2 production after 14 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed