BDBM50518039 CHEMBL4467883::US11498896, Compound 90

SMILES CC1(CCN(CCOc2ccccc2C(F)(F)F)CC1)Oc1ccc(Cl)cc1

InChI Key InChIKey=MLQFCCRYUWOUAD-UHFFFAOYSA-N

Data  1 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50518039   

TargetD(2) dopamine receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50518039(CHEMBL4467883 | US11498896, Compound 90)
Affinity DataEC50:  61nMAssay Description:Agonist activity at dopamine D2long receptor (unknown origin) assessed as increased in cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50518039(CHEMBL4467883 | US11498896, Compound 90)
Affinity DataEC50:  540nMAssay Description:Antagonist activity at dopamine D2long receptor (unknown origin) assessed as inhibition of agonist-induced beta-arrestin recruitmentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50518039(CHEMBL4467883 | US11498896, Compound 90)
Affinity DataKi:  550nMAssay Description:The D2 binding Ki values were determined using a radioligand binding assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2023
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50518039(CHEMBL4467883 | US11498896, Compound 90)
Affinity DataEC50:  600nMAssay Description:Agonist activity at dopamine D2long receptor (unknown origin) assessed as increase in beta-arrestin recruitmentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50518039(CHEMBL4467883 | US11498896, Compound 90)
Affinity DataEC50: >3.00E+4nMAssay Description:Antagonist activity at dopamine D2long receptor (unknown origin) assessed as inhibition of agonist-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed