BDBM50518408 CHEMBL4483816

SMILES Cc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3csc4c(N)ncnc34)c12

InChI Key InChIKey=KZVIZFHCMVWFNT-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50518408   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518408(CHEMBL4483816)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at recombinant human N-terminal His6-tagged FMS (538 to end residues) expressed in baculovirus infected Sf21 insect cells using I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518408(CHEMBL4483816)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518408(CHEMBL4483816)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518408(CHEMBL4483816)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518408(CHEMBL4483816)
Affinity DataIC50: 145nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged FGFR1 (456 to 765 residues) expressed in baculovirus infected Sf21 insect cells using IGF-IRtid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518408(CHEMBL4483816)
Affinity DataIC50: 527nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged KDR (790 to end residues) expressed in baculovirus infected Sf21 insect cells using MBP as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518408(CHEMBL4483816)
Affinity DataIC50: 208nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged Tie2 (771 to end residues) expressed in baculovirus infected Sf21 insect cells using Poly (Glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518408(CHEMBL4483816)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518408(CHEMBL4483816)
Affinity DataIC50: 64nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged DDR2 (467 to end residues) expressed in baculovirus infected Sf21 insect cells using Axltide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518408(CHEMBL4483816)
Affinity DataIC50: 5.00E+4nMAssay Description:Displacement of Tracer Red from human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518408(CHEMBL4483816)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518408(CHEMBL4483816)
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged c-RAF Y340D/Y341D double mutant (306 to 648 residues) expressed in baculovirus infected Sf21 in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMaternal embryonic leucine zipper kinase(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518408(CHEMBL4483816)
Affinity DataIC50: 258nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged MELK (1 to 340 residues) expressed in baculovirus infected Sf21 insect cells using KKLNRTLSFAEP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Chung-Ang University

Curated by ChEMBL
LigandPNGBDBM50518408(CHEMBL4483816)
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed