BDBM50518462 CHEMBL4483681

SMILES [H][C@]12CCC[C@H](N3CCCC3)[C@@]1([H])N(CCN2C(=O)OC(C)(C)C)C(=O)Cc1ccc(Cl)c(Cl)c1

InChI Key InChIKey=QYKOMVKBDKOREW-UHFFFAOYSA-N

Data  4 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50518462   

TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518462(CHEMBL4483681)
Affinity DataEC50:  42nMAssay Description:Agonist activity at Tango-KOR (unknown origin) expressed in HTLA cells harboring TEV-fused-beta-arrestin 2 assessed as increase in beta arrestin 2 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518462(CHEMBL4483681)
Affinity DataEC50:  8.10nMAssay Description:Agonist activity at human KOR expressed in HEK293T cells assessed as inhibition of Galphai-mediated cAMP accumulation after 15 mins by microbeta coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518462(CHEMBL4483681)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]U-69,593 from KOR in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518462(CHEMBL4483681)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]diprenorphine from human KOR expressed in HEK293T cell membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518462(CHEMBL4483681)
Affinity DataKi:  260nMAssay Description:Displacement of [3H]DAMGO from MOR in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50518462(CHEMBL4483681)
Affinity DataKi:  438nMAssay Description:Displacement of [3H]DPDPE from DOR in Sprague-Dawley rat brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed