BDBM50518960 CHEMBL4459978

SMILES CCC(=O)N[C@H]1CC[C@H](CC1)n1c2nc(Nc3ccc(N4CCN(C)CC4)c(C)c3)ncc2c(C)c(-c2ccccc2Cl)c1=O

InChI Key InChIKey=LGWUFYZACXZEFK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50518960   

TargetEpidermal growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50518960(CHEMBL4459978)
Affinity DataIC50: 169nMAssay Description:Inhibition of wild-type EGFR (unknown origin) using Poly(Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50518960(CHEMBL4459978)
Affinity DataIC50: 518nMAssay Description:Inhibition of human C-terminal His-tagged and N-terminal GST-tagged EGFR L858R/T790M/C797S triple mutant ( 668 to 1210 amino acids) expressed in bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50518960(CHEMBL4459978)
Affinity DataIC50: 519nMAssay Description:Inhibition of human C-terminal His-tagged and N-terminal GST-tagged EGFR L858R/T790M/C797S triple mutant ( 668 to 1210 amino acids) expressed in bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50518960(CHEMBL4459978)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of wild-type EGFR (unknown origin) using Poly(Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed