BDBM50519029 CHEMBL4524567

SMILES OC(=O)[C@@H](Cc1ccccc1)Nc1ncnc2sc(c(-c3cccc(O)c3)c12)-c1ccccc1

InChI Key InChIKey=QCWRZLCYTPTRAK-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50519029   

TargetApoptosis regulator Bcl-2(Human)
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50519029(CHEMBL4524567)
Affinity DataKi:  2.10E+4nMAssay Description:Displacement of N-terminal fluorescein labelled Puma-BH3 peptide from human N-terminal thrombin cleavage site-fused/His6-tagged Bcl-2 expressed in Es...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50519029(CHEMBL4524567)
Affinity DataKi:  2.40E+4nMAssay Description:Displacement of N-terminal fluorescein labelled Puma-BH3 peptide from TEV-fused His-tagged human Mcl-1 expressed in Escherichia coliBL21(DE3) pLysS c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed