BDBM50520104 CHEMBL4535971

SMILES C\C=C\c1nnn(Cc2ccc(cc2)C(F)(F)F)c1C(=O)N[C@@H](C)c1ccc(cc1)C(O)=O

InChI Key InChIKey=ZTWUZRMXAVDXJV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50520104   

TargetProstaglandin E2 receptor EP4 subtype(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50520104(CHEMBL4535971)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human EP4 transfected in human HEK293 cells co transfected with SmBit-beta-arrestin. assessed as reduction in PGE2 induced-beta-arresti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50520104(CHEMBL4535971)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human EP4 transfected in human HEK293 cells co transfected with CRE-luciferase assessed as reduction in PGE2-induced luciferase express...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50520104(CHEMBL4535971)
Affinity DataIC50: 6.10nMAssay Description:Antagonist activity at human EP4 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50520104(CHEMBL4535971)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at mouse EP4 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50520104(CHEMBL4535971)
Affinity DataIC50: 19nMAssay Description:Inhibition of human EP4 transfected in human HEK293 cells assessed as reduction in PGE2-induced cAMP level incubated for 15 mins followed by PGE2 sti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50520104(CHEMBL4535971)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human EP1 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50520104(CHEMBL4535971)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human EP3 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50520104(CHEMBL4535971)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human EP2 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed