BDBM50520471 CHEMBL4592669

SMILES CCOc1ccc(CNCc2ccccc2)cc1CNC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C

InChI Key InChIKey=LRDUUAOPCJUHPW-UHFFFAOYSA-N

Data  3 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50520471   

TargetMu-type opioid receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50520471(CHEMBL4592669)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]diprenorphine from human MOR expressed in CHO cell membranes incubated for 1 hr by liquid scintillation counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50520471(CHEMBL4592669)
Affinity DataKi:  0.820nMAssay Description:Displacement of [3H]diprenorphine from human DOR expressed in CHO cell membranes incubated for 1 hr by liquid scintillation counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50520471(CHEMBL4592669)
Affinity DataEC50:  4.70nMAssay Description:Agonist activity at human DOR expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding incubated for 1 hr by by liquid scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50520471(CHEMBL4592669)
Affinity DataEC50:  17nMAssay Description:Agonist activity at human MOR expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding incubated for 1 hr by by liquid scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50520471(CHEMBL4592669)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]diprenorphine from human KOR expressed in CHO cell membranes incubated for 1 hr by liquid scintillation counting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50520471(CHEMBL4592669)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human KOR expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding incubated for 1 hr by by liquid scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed