BDBM50520948 CHEMBL4443524

SMILES CNC(=O)c1c(oc2ccc(O)c(CN3CCCCC3)c12)-c1ccc(O)cc1

InChI Key InChIKey=PQGCMFVNJWTUFH-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50520948   

TargetPolyketide synthase Pks13(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Huanghuai University

Curated by ChEMBL
LigandPNGBDBM50520948(CHEMBL4443524)
Affinity DataIC50: 499nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv N-terminal His6-tagged Pks13 thioesterase domain expressed in Escherichia coli BL21(DE3) using 4-MUH a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPolyketide synthase Pks13(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Huanghuai University

Curated by ChEMBL
LigandPNGBDBM50520948(CHEMBL4443524)
Affinity DataIC50: 320nMAssay Description:Inhibition of Mycobacterium tuberculosis Pks13-TE domain using 4-methylumbelliferyl heptanoate as a fluorogenic substrate measured for 110 mins at 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50520948(CHEMBL4443524)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of hERG ion channel by Q patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50520948(CHEMBL4443524)
Affinity DataIC50: 38nMAssay Description:Inhibition of hERG expressed in CHO cells Qpatch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50520948(CHEMBL4443524)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of hERG transfected in T-REX-CHO cells incubated for 30 mins by BTC-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPolyketide synthase Pks13(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Huanghuai University

Curated by ChEMBL
LigandPNGBDBM50520948(CHEMBL4443524)
Affinity DataIC50: 190nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv Pks13 expressed in Escherichia coli BL21 (DE3)pLysS cells measured for 80 to 120 mins by 4-MUH assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPolyketide synthase Pks13(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Huanghuai University

Curated by ChEMBL
LigandPNGBDBM50520948(CHEMBL4443524)
Affinity DataIC50: 200nMAssay Description:Inhibition of Mycobacterium tuberculosis N-terminal His-6 tagged Pks13 thioesterase domain expressed in Escherichia coli BL21 (DE3) using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed