BDBM50521121 CHEMBL4459443

SMILES COc1ccc(cc1)S(=O)(=O)N1CCc2cccc(NCc3ccc(cc3)C(=O)Nc3ccccc3N)c12

InChI Key InChIKey=YTEDLDZSZVMYSV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50521121   

TargetHistone deacetylase 1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50521121(CHEMBL4459443)
Affinity DataIC50: 221nMAssay Description:Inhibition of human HDAC1 using RHKKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50521121(CHEMBL4459443)
Affinity DataIC50: 314nMAssay Description:Inhibition of human HDAC6 using RHKKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50521121(CHEMBL4459443)
Affinity DataIC50: 662nMAssay Description:Inhibition of human HDAC2 using RHKKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50521121(CHEMBL4459443)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization measured every 30 secs for 30 mins by turbidimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50521121(CHEMBL4459443)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HDAC10 using RHKKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed