BDBM50521142 CHEMBL4438964

SMILES Clc1ccccc1CN1CCC(CNCc2cccc(c2)-c2ccccc2)CC1

InChI Key InChIKey=XBEBHNXBLIDZDS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50521142   

TargetC-X-C chemokine receptor type 4(Human)
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50521142(CHEMBL4438964)
Affinity DataIC50: 501nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR4 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50521142(CHEMBL4438964)
Affinity DataIC50: 631nMAssay Description:Displacement of CXCL12-red from human NLuc-tagged CXCR4 receptor expressed in HEK293T cell membranes after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50521142(CHEMBL4438964)
Affinity DataIC50: 1.26E+3nMAssay Description:Antagonist activity at human DEF3-fused CXCR4 receptor expressed in HEK293T cells co-expressing DAN1-HA-Galphaq/i5 assessed as inhibition of CXCL12-i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50521142(CHEMBL4438964)
Affinity DataIC50: 2.51E+3nMAssay Description:Antagonist activity at human DEF3-RLuc fused CXCR4 receptor expressed in HEK293T cells co-expressing DEF3-Beta-arrestin-2-mVenus assessed as inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed