BDBM50521156 CHEMBL4452433

SMILES Cc1cccc(CNCC2CCN(Cc3ccccc3Cl)CC2)c1

InChI Key InChIKey=JFSVPTKSONMNBC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50521156   

TargetC-X-C chemokine receptor type 4(Human)
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50521156(CHEMBL4452433)
Affinity DataIC50: 158nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR4 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50521156(CHEMBL4452433)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human DEF3-fused CXCR4 receptor expressed in HEK293T cells co-expressing DAN1-HA-Galphaq/i5 assessed as inhibition of CXCL12-i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50521156(CHEMBL4452433)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of CXCL12-red from human NLuc-tagged CXCR4 receptor expressed in HEK293T cell membranes after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50521156(CHEMBL4452433)
Affinity DataIC50: 3.16E+3nMAssay Description:Antagonist activity at human DEF3-RLuc fused CXCR4 receptor expressed in HEK293T cells co-expressing DEF3-Beta-arrestin-2-mVenus assessed as inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed