BDBM50521329 CHEMBL4468037

SMILES CC(C)(C)c1ccc(cc1Cl)N1[C@@H]([C@@H](C(O)=O)c2ccccc2C1=O)c1ccc2OCCOc2c1

InChI Key InChIKey=XGDKZTMGSABEJP-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50521329   

LigandPNGBDBM50521329(CHEMBL4468037)
Affinity DataIC50: 1.15E+4nMAssay Description:Antagonist activity at STING in human THP1 cells assessed as inhibition of cGAMP-induced IFNbeta production pretreated for 6 hrs followed by cGAMP ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521329(CHEMBL4468037)
Affinity DataIC50: 84nMAssay Description:Displacement of [3H]cGAMP from full length human HAQ STING expressed in Trichopulsia ni membranes preincubated for 30 mins followed by [3H]cGAMP addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521329(CHEMBL4468037)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at STING in human THP1 cells assessed as stimulation of IFNbeta production measured after 5 hrs by Alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed