BDBM50521336 CHEMBL4453120

SMILES COc1cc(cnc1OC)-c1cc2CN(C(=O)c2c(C)n1)c1cnn(CC(F)(F)F)c1

InChI Key InChIKey=JKHNKIJWVXHBDL-UHFFFAOYSA-N

Data  1 KI  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50521336   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Vertex Pharmaceuticals

Curated by ChEMBL

LigandBDBM50521336(CHEMBL4453120)Copy SMILESCopy InChI

Affinity DataKi:  14nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate measured after 15 mins in presence of [33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy BDB DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Vertex Pharmaceuticals

Curated by ChEMBL

LigandBDBM50521336(CHEMBL4453120)Copy SMILESCopy InChI

Affinity DataIC50: 270nMAssay Description:Inhibition of PI3Kgamma in human THP1 cells assessed as reduction in MCP1-induced Akt phosphorylation at Thr308/Ser473 residue preincubated for 1 hr ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL