BDBM50521471 CHEMBL4439404

SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn(CC=C)c3ncnc(N)c23)no1

InChI Key InChIKey=XIMGYPHSYIMHAW-UHFFFAOYSA-N

Data  2 IC50  10 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50521471   

LigandPNGBDBM50521471(CHEMBL4439404)
Affinity DataKd:  2.40nMAssay Description:Binding affinity to human partial length FLT3 N841I mutant (V592 to Y969 residues) expressed in Escherichia coli after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521471(CHEMBL4439404)
Affinity DataKd:  2.5nMAssay Description:Binding affinity to human partial length FLT3 K663Q mutant (V592 to Y969 residues) expressed in Escherichia coli after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521471(CHEMBL4439404)
Affinity DataKd:  4.40nMAssay Description:Binding affinity to wild-type human partial length FLT3 (V592 to Y969 residues) expressed in Escherichia coli after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521471(CHEMBL4439404)
Affinity DataKd:  5.10nMAssay Description:Binding affinity to human partial length FLT3 D835H mutant (V592 to Y969 residues) expressed in Escherichia coli after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521471(CHEMBL4439404)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human FLT3 (564 to end residues) using EAIYAAPFAKKK as substrate measured after 40 mins in presence of [gamma-33P]-ATP by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521471(CHEMBL4439404)
Affinity DataKd:  7nMAssay Description:Binding affinity to human partial length FLT3 D835V mutant (V592 to Y969 residues) expressed in Escherichia coli after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521471(CHEMBL4439404)
Affinity DataKd:  7.80nMAssay Description:Binding affinity to human partial length FLT3 D835Y mutant (Q580 to Y969 residues) expressed in Escherichia coli after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521471(CHEMBL4439404)
Affinity DataKd:  10nMAssay Description:Binding affinity to human partial length FLT3 R834Q mutant (V592 to Y969 residues) expressed in HEK293 cells measured after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521471(CHEMBL4439404)
Affinity DataKd:  21nMAssay Description:Binding affinity to human partial length FLT3 ITD mutant expressed in Escherichia coli measured after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521471(CHEMBL4439404)
Affinity DataKd:  41nMAssay Description:Binding affinity to human partial length FLT3 ITD/D835V double mutant expressed in Escherichia coli after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521471(CHEMBL4439404)
Affinity DataKd:  48nMAssay Description:Binding affinity to human partial length FLT3 ITD/F691L double mutant expressed in Escherichia coli after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50521471(CHEMBL4439404)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant human c-Kit (544 to end residues) using poly(Glu, Tyr) 4:1 as substrate measured after 40 mins in presence of [gamma-33P]-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed