BDBM50521996 CHEMBL4459940

SMILES Cc1c(cnn1-c1ccc(F)cc1)C(=O)Nc1nc(C2CCC2)c(CCN2CCCCC2)s1

InChI Key InChIKey=AMCRGAFJVJDYAS-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50521996   

TargetTransient receptor potential cation channel subfamily V member 4(Human)
Astellas Pharma

Curated by ChEMBL

LigandBDBM50521996(CHEMBL4459940)Copy SMILESCopy InChI

Affinity DataIC50: 0.850nMAssay Description:Inhibition of human TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
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TargetTransient receptor potential cation channel subfamily V member 4(Rat)
Astellas Pharma

Curated by ChEMBL

LigandBDBM50521996(CHEMBL4459940)Copy SMILESCopy InChI

Affinity DataIC50: 1.10nMAssay Description:Inhibition of rat TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL