BDBM50522309 CHEMBL4532536

SMILES Cc1ccc(cc1)S(=O)(=O)N1C(=O)NC2(CCCc3ccccc23)C1=O

InChI Key InChIKey=LXXQXOMQCGHKBG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50522309   

TargetAldo-keto reductase family 1 member B1(Rat)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50522309(CHEMBL4532536)
Affinity DataIC50: 1.56E+3nMAssay Description:Inhibition of ALR2 in rat lens assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chromatographic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Rat)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50522309(CHEMBL4532536)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of ALR2 in rat erythrocytes assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chromat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Rat)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50522309(CHEMBL4532536)
Affinity DataIC50: 1.72E+3nMAssay Description:Inhibition of ALR2 in rat sciatic nerve assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chroma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50522309(CHEMBL4532536)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human recombinant ALR2 expressed in Escherichia coli using DL-glyceraldehyde as substrate and NADPH preincubated for 5 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed