BDBM50522627 CHEMBL4590743

SMILES COc1cc2[nH]c(cc2cc1C#N)-c1nc2C(CCCn2n1)c1ccccc1C(F)(F)F

InChI Key InChIKey=LXYWOOBKIKICMZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50522627   

TargetPresenilin-1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50522627(CHEMBL4590743)
Affinity DataIC50: 107nMAssay Description:Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed