BDBM50522635 CHEMBL4542879

SMILES COc1c(ccc2[nH]c(cc12)-c1cn2CCO[C@H](c2n1)c1c(F)cccc1C(F)(F)F)C#N

InChI Key InChIKey=AOISQQKLSIPOKV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50522635   

TargetPresenilin-1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50522635(CHEMBL4542879)
Affinity DataIC50: 36nMAssay Description:Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed