BDBM50522644 CHEMBL4582605

SMILES COc1c(ccc2[nH]c(cc12)-c1cn2CCO[C@@H](c2n1)c1ccccc1C(F)(F)F)C#N

InChI Key InChIKey=ZOVFQRDNBWHWDZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50522644   

TargetPresenilin-1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50522644(CHEMBL4582605)
Affinity DataIC50: 347nMAssay Description:Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed