BDBM50523409 CHEMBL4483725

SMILES CN(C)c1ccc(CNC(=O)[C@@H]2CNC[C@H]2c2ccc(c(F)c2)C(F)(F)F)cc1

InChI Key InChIKey=ONLUGUMUKZHJAF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50523409   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Saint Louis University

Curated by ChEMBL
LigandPNGBDBM50523409(CHEMBL4483725)
Affinity DataIC50: 8.54E+3nMAssay Description:Inhibition of Tracer Red binding to human ERG expressed in membranes by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Saint Louis University

Curated by ChEMBL
LigandPNGBDBM50523409(CHEMBL4483725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human C-terminal His10-tagged BACE1 using Mca-SEVNLDAEFRK(Dpn)RR-NH2 as substrate measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetPlasmepsin IV [1-448](malaria parasite P. falciparum)
Saint Louis University

Curated by ChEMBL
LigandPNGBDBM50523409(CHEMBL4483725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 4 using EDANS-CO-CH2-CH2-CO-ALERMFLSFP-Dap(DABCYL)OH as substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

Curated by ChEMBL
LigandPNGBDBM50523409(CHEMBL4483725)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2 using EDANS-CO-CH2-CH2-CO-ALERMFLSFP-Dap(DABCYL)OH as substrate measured after 60 mins by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed