BDBM50523474 CHEMBL4473652

SMILES Cc1cccc(NC(=O)CN2CCN(CC2)c2cccc3ccccc23)c1

InChI Key InChIKey=LEQVQRFGBPYNQZ-UHFFFAOYSA-N

Data  6 KI  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50523474   

TargetD(4) dopamine receptor(Human)
Rowan University

Curated by ChEMBL
LigandPNGBDBM50523474(CHEMBL4473652)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H](R)-(+)-7-OH-DPAT from human D4.4 receptor expressed in HEK293 cell membranes measured after 90 mins by scintillation counting me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Rowan University

Curated by ChEMBL
LigandPNGBDBM50523474(CHEMBL4473652)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]N-methylspiperone from human D4.4 receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Rowan University

Curated by ChEMBL
LigandPNGBDBM50523474(CHEMBL4473652)
Affinity DataEC50:  109nMAssay Description:Agonist activity at human D4 receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Rowan University

Curated by ChEMBL
LigandPNGBDBM50523474(CHEMBL4473652)
Affinity DataKi:  200nMAssay Description:Displacement of [3H](R)-(+)-7-OH-DPAT from human D2L receptor expressed in HEK293 cell membranes measured after 90 mins by scintillation counting met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Rowan University

Curated by ChEMBL
LigandPNGBDBM50523474(CHEMBL4473652)
Affinity DataKi:  1.25E+3nMAssay Description:Displacement of [3H](R)-(+)-7-OH-DPAT from human D3 receptor expressed in HEK293 cell membranes measured after 90 mins by scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Rowan University

Curated by ChEMBL
LigandPNGBDBM50523474(CHEMBL4473652)
Affinity DataKi:  1.49E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human D2L receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Rowan University

Curated by ChEMBL
LigandPNGBDBM50523474(CHEMBL4473652)
Affinity DataIC50: 2.52E+3nMAssay Description:Antagonist activity at human D4 receptor expressed in CHOK1 cells assessed as suppression of dopamine-induced inhibition of forskolin-stimulated cAMP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Rowan University

Curated by ChEMBL
LigandPNGBDBM50523474(CHEMBL4473652)
Affinity DataIC50: 4.25E+3nMAssay Description:Antagonist activity at human D4 receptor expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta-arrestin recruitment measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Rowan University

Curated by ChEMBL
LigandPNGBDBM50523474(CHEMBL4473652)
Affinity DataEC50:  9.21E+3nMAssay Description:Agonist activity at human D4 receptor expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by luminesce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Rowan University

Curated by ChEMBL
LigandPNGBDBM50523474(CHEMBL4473652)
Affinity DataKi:  1.15E+4nMAssay Description:Displacement of [3H]N-methylspiperone from human D3 receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Rowan University

Curated by ChEMBL
LigandPNGBDBM50523474(CHEMBL4473652)
Affinity DataIC50: 6.83E+4nMAssay Description:Antagonist activity at human D2L receptor expressed in CHOK1 cells assessed as suppression of dopamine-induced inhibition of forskolin-stimulated cAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Rowan University

Curated by ChEMBL
LigandPNGBDBM50523474(CHEMBL4473652)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human D2L receptor expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta-arrestin recruitment measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed