BDBM50523959 CHEMBL4584968

SMILES ONC(=O)[C@@H]1C[C@H](O)CN1C(=O)c1ccc(cc1)C#Cc1ccc(OCCCCCF)cc1

InChI Key InChIKey=LXWCLFCLBYYKME-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50523959   

TargetCollagenase 3(Human)
University of Hamburg

Curated by ChEMBL
LigandPNGBDBM50523959(CHEMBL4584968)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of human MMP13 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl)Ala-Arg-NH2 as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Hamburg

Curated by ChEMBL
LigandPNGBDBM50523959(CHEMBL4584968)
Affinity DataIC50: 5nMAssay Description:Inhibition of human MMP2 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl)Ala-Arg-NH2 as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
University of Hamburg

Curated by ChEMBL
LigandPNGBDBM50523959(CHEMBL4584968)
Affinity DataIC50: 21nMAssay Description:Inhibition of human MMP8 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl)Ala-Arg-NH2 as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Hamburg

Curated by ChEMBL
LigandPNGBDBM50523959(CHEMBL4584968)
Affinity DataIC50: 108nMAssay Description:Inhibition of human MMP9 using (7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl)Ala-Arg-NH2 as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed