BDBM50524298 CHEMBL4577258

SMILES CNc1nc(Nc2cnc(C#N)c(O[C@@H]3CCCNC3)c2)ncc1-c1cnn(C)c1

InChI Key InChIKey=SLCNIAWQMQCAFR-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50524298   

TargetSerine/threonine-protein kinase Chk1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50524298(CHEMBL4577258)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged CHK1 (M1 to T476 residues) expressed in baculovirus infected insect cells using biotin-labelled...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50524298(CHEMBL4577258)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human C-terminal His-tagged FLT3 (M1 to N541 residues) expressed in HEK293 cells using biotin-labelled STK substrate-1 as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50524298(CHEMBL4577258)
Affinity DataIC50: 108nMAssay Description:Inhibition of AMPKalpha1beta1gamma1 (unknown origin) using biotin-labelled STK substrate-1 as substrate incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50524298(CHEMBL4577258)
Affinity DataIC50: 512nMAssay Description:Inhibition of recombinant human full length N-terminal His-tagged PIM1 (1 to 313 residues) expressed in baculovirus expression system using biotin-la...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50524298(CHEMBL4577258)
Affinity DataIC50: 626nMAssay Description:Inhibition of p70S6K (unknown origin) using biotin-labelled STK substrate-1 as substrate incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50524298(CHEMBL4577258)
Affinity DataIC50: 736nMAssay Description:Inhibition of PIM3 (unknown origin) incubated for 60 mins using biotin-labelled STK substrate-1 as substrate by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50524298(CHEMBL4577258)
Affinity DataIC50: 1.73E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged CHK2 (M1 to L543 residues) expressed in baculovirus infected insect cells using biotin-labelled...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50524298(CHEMBL4577258)
Affinity DataIC50: 2.71E+3nMAssay Description:Inhibition of BLK (unknown origin) using biotin-labelled STK substrate-1 as substrate incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50524298(CHEMBL4577258)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of LCK (unknown origin) incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50524298(CHEMBL4577258)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of LYN (unknown origin) incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50524298(CHEMBL4577258)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK1 (unknown origin) using biotin-labelled STK substrate-1 as substrate incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50524298(CHEMBL4577258)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2 (unknown origin) using biotin-labelled STK substrate-1 as substrate incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein kinase C epsilon type(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50524298(CHEMBL4577258)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKCepsilon (unknown origin) using biotin-labelled STK substrate-1 as substrate incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed