BDBM50524490 CHEMBL4561244

SMILES Nc1nc2c(ccnc2[nH]1)-c1ccncc1F

InChI Key InChIKey=AYORLAGKWMLGEX-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50524490   

TargetOxidized purine nucleoside triphosphate hydrolase(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50524490(CHEMBL4561244)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant His-tagged MTH1 (unknown origin) expressed in Escherichia coli BL21(DE3) cells using dGTP as substrate incubated for 15 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50524490(CHEMBL4561244)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of BACE1 (unknown origin) using HiLyte Fluo488/QXL-520 as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50524490(CHEMBL4561244)
Affinity DataKd:  100nMAssay Description:Binding affinity to recombinant His-tagged MTH1 (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as dissociation constant by isother...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed