BDBM50525178 CHEMBL4437852

SMILES Nc1ccccc1NC(=O)c1ccc(CSc2nccc(n2)C(F)(F)F)cc1

InChI Key InChIKey=GMXVQBBEKILTMI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50525178   

TargetHistone deacetylase 1(Human)
Beijing University of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50525178(CHEMBL4437852)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human His tagged HDAC1 expressed in baculovirus infected insect cells assessed as decrease in deacetylation of FLUOR DE LYS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetNuclear receptor corepressor 1(Human)
Beijing University of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50525178(CHEMBL4437852)
Affinity DataIC50: 274nMAssay Description:Inhibition of recombinant human HDAC3/NCOR1 assessed as decrease in deacetylation of FLUOR DE LYS SIRT1 substrate preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Beijing University of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50525178(CHEMBL4437852)
Affinity DataIC50: 441nMAssay Description:Inhibition of recombinant human HDAC2 assessed as decrease in deacetylation of FLUOR DE LYS Green substrate preincubated for 10 mins followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Beijing University of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50525178(CHEMBL4437852)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract assessed as decrease in deacetylation of FLUOR DE LYS Green substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Beijing University of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50525178(CHEMBL4437852)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of recombinant human His tagged HDAC6 expressed in baculovirus infected insect cells assessed as decrease in deacetylation of FLUOR DE LYS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Beijing University of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50525178(CHEMBL4437852)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of recombinant human HDAC8 assessed as decrease in deacetylation of FLUOR DE LYS substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed