BDBM50525661 CHEMBL4459795

SMILES ONC(=O)\C=C\c1ccc(CONC(=O)c2ccc3ccccc3n2)cc1

InChI Key InChIKey=SCYAVNQVZVEEPH-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50525661   

TargetHistone deacetylase 2(Human)
Heinrich-Heine-University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM50525661(CHEMBL4459795)
Affinity DataKi:  70nMAssay Description:Inhibition of C-terminal GST-tagged recombinant human HDAC2 (1 to 488 residues) expressed in Baculovirus infected insect cells using Boc-Lys(Ac)-AMC ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Heinrich-Heine-University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM50525661(CHEMBL4459795)
Affinity DataKi:  100nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human HDAC6 (1 to 1215 residues) expressed in Baculovirus infected insect cells using Boc-Lys(Ac)-AMC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Heinrich-Heine-University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM50525661(CHEMBL4459795)
Affinity DataIC50: 270nMAssay Description:Inhibition of HDAC in human CAL27 cells using Boc-Lys(epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate addition and further...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Heinrich-Heine-University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM50525661(CHEMBL4459795)
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of HDAC in human A2780 cells using Boc-Lys(epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate addition and further...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Heinrich-Heine-University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM50525661(CHEMBL4459795)
Affinity DataKi:  4.70E+3nMAssay Description:Inhibition of C-terminal His-fusion tagged/N-terminal Strep-2 tagged recombinant human HDAC8 (1 to 377 residues) expressed in insect cells using Boc-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Heinrich-Heine-University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM50525661(CHEMBL4459795)
Affinity DataKi:  9.54E+3nMAssay Description:Inhibition of C-terminal His-tagged/N-terminal GST-tagged recombinant human HDAC4 (627 to 1084 residues) expressed in Baculovirus infected insect cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed