BDBM50526281 CHEMBL4576457

SMILES CC(=O)N[C@H]1CC[C@@H](CC1)Nc1cc(Cl)nn2c(cnc12)-c1ccc2[nH]ncc2c1

InChI Key InChIKey=IFDGNKABCXNEJL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50526281   

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester

Curated by ChEMBL
LigandPNGBDBM50526281(CHEMBL4576457)
Affinity DataIC50: 33nMAssay Description:Inhibition of dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) -dependent cleavage of FAM-labeled stem-loop RNA containing the XBP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester

Curated by ChEMBL
LigandPNGBDBM50526281(CHEMBL4576457)
Affinity DataIC50: 140nMAssay Description:Displacement for LanthaScreen tracer from dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) ATP binding site KEN domain after 60 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester

Curated by ChEMBL
LigandPNGBDBM50526281(CHEMBL4576457)
Affinity DataIC50: 150nMAssay Description:Inhibition of dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) autophosphorylation at S724 after 25 mins in presence of ATP by dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed