BDBM50526309 CHEMBL4543331

SMILES CCOc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](CC)N(Cc3sccc3C)c2n1)C1CCN(C)CC1

InChI Key InChIKey=IJNMRIYHRCSVCO-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50526309   

TargetBromodomain-containing protein 4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526309(CHEMBL4543331)
Affinity DataKd:  63nMAssay Description:Binding affinity to BRD4 (unknown origin) by isothermal calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526309(CHEMBL4543331)
Affinity DataIC50: 310nMAssay Description:Inhibition of full-length C-terminal NanoLuc-tagged BRD4 BD1 (unknown origin) expressed in human HEK293 cells after 2 hrs by NanoBRET target engageme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526309(CHEMBL4543331)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of full-length C-terminal NanoLuc-tagged ALK (unknown origin) expressed in human HEK293 cells after 2 hrs by NanoBRET target engagement as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526309(CHEMBL4543331)
Affinity DataIC50: 63nMAssay Description:Displacement of kinase tracer 236 from human N-terminal GST-tagged ALK F1174L mutant (1058 to 1620 residues) after 60 mins by LanthaScreen Eu--kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50526309(CHEMBL4543331)
Affinity DataIC50: 68nMAssay Description:Inhibition of PLK1 (unknown origin) using Ser/Thr 16 as substrate after 60 mins by Z-LYTE activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed