BDBM50526578 CHEMBL4468490

SMILES [H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)n1ccc2c(N)ncnc12

InChI Key InChIKey=LCYHXWIEMRESTK-UHFFFAOYSA-M

Data  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50526578   

TargetRap guanine nucleotide exchange factor 3(Human)
University Hospital Jena

Curated by ChEMBL
LigandPNGBDBM50526578(CHEMBL4468490)
Affinity DataEC50:  2.75E+3nMAssay Description:Inhibition of 8Fluo-cAMP binding to recombinant human His-tagged EPAC1 (157 to 881 residues) expressed in Escherichia coli measured after 5 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclic nucleotide-gated olfactory channel(Rat)
University Hospital Jena

Curated by ChEMBL
LigandPNGBDBM50526578(CHEMBL4468490)
Affinity DataEC50:  2.08E+3nMAssay Description:Activation of recombinant rat CNGA2 expressed in Xenopus laevis oocyte assessed as increase in current amplitude by patch-clamp electrophysiology met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Mouse)
University Hospital Jena

Curated by ChEMBL
LigandPNGBDBM50526578(CHEMBL4468490)
Affinity DataEC50:  2.06E+3nMAssay Description:Inhibition of 8Fluo-cAMP binding to DEP domain deficient mouse EPAC2 (280 to 988 residues) measured after 5 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclic nucleotide-gated olfactory channel(Rat)
University Hospital Jena

Curated by ChEMBL
LigandPNGBDBM50526578(CHEMBL4468490)
Affinity DataEC50:  360nMAssay Description:Activation of recombinant rat CNGA2/CNGA4/CNGB1b heterotetramer expressed in Xenopus laevis oocyte assessed as increase in current amplitude by patch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50526578(CHEMBL4468490)
Affinity DataEC50:  15nMAssay Description:Activation of recombinant mouse HCN2 expressed in Xenopus laevis oocyte assessed as increase in current amplitude at -30 mV holding potential by patc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed