BDBM50526603 CHEMBL4293907

SMILES CNc1cc(Nc2cc(C)cc(C)c2)nn2c(cnc12)C(=O)NC1CC1

InChI Key InChIKey=UNAWOCNJDJPOHK-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50526603   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50526603(CHEMBL4293907)
Affinity DataKi:  0.130nMAssay Description:Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50526603(CHEMBL4293907)
Affinity DataKi:  0.130nMAssay Description:Inhibition of TYK2 JH2 domain (unknown origin) in presence of 10 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50526603(CHEMBL4293907)
Affinity DataKi:  96nMAssay Description:Inhibition of TYK2 JH2 domain in IFNalpha/IL23-stimulated human Kit225 cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526603(CHEMBL4293907)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of JAK1 JH1 domain (unknown origin) in presence of 10 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526603(CHEMBL4293907)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of JAK2 JH1 domain (unknown origin) in presence of 10 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526603(CHEMBL4293907)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of JAK3 JH1 domain (unknown origin) in presence of 10 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50526603(CHEMBL4293907)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) in presence of 10 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed