BDBM50526606 CHEMBL4532948::US11174264, Compound I-3

SMILES CNc1cc(Nc2cccn(-c3ccccn3)c2=O)nn2c(cnc12)C(=O)N[C@@H]1C[C@@H]1F

InChI Key InChIKey=YITUGUNLCGLOII-UHFFFAOYSA-N

Data  8 KI  6 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50526606   

TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50526606(CHEMBL4532948 | US11174264, Compound I-3)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of JAK1 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50526606(CHEMBL4532948 | US11174264, Compound I-3)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50526606(CHEMBL4532948 | US11174264, Compound I-3)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50526606(CHEMBL4532948 | US11174264, Compound I-3)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of JAK3 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50526606(CHEMBL4532948 | US11174264, Compound I-3)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50526606(CHEMBL4532948 | US11174264, Compound I-3)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of JAK2 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshmi

US Patent
LigandPNGBDBM50526606(CHEMBL4532948 | US11174264, Compound I-3)
Affinity DataKd: <0.200nMAssay Description:The binding reaction was assembled by combining 16 μl of DNA-tagged kinase extract, 3.8 μl liganded affinity beads, and 0.18 μl test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50526606(CHEMBL4532948 | US11174264, Compound I-3)
Affinity DataKi:  0.0860nMAssay Description:Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50526606(CHEMBL4532948 | US11174264, Compound I-3)
Affinity DataKi:  0.0860nMAssay Description:Inhibition of TYK2 JH2 domain (unknown origin) in presence of 10 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50526606(CHEMBL4532948 | US11174264, Compound I-3)
Affinity DataKi:  25nMAssay Description:Inhibition of TYK2 JH2 domain in IFNalpha/IL23-stimulated human Kit225 cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50526606(CHEMBL4532948 | US11174264, Compound I-3)
Affinity DataKi:  81nMAssay Description:Inhibition of TYK2 JH2 domain in human whole blood assessed as decrease in IFNalpha/IL2-induced STAT phosphorylation preincubated for 1 hr followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50526606(CHEMBL4532948 | US11174264, Compound I-3)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of JAK1 JH1 domain (unknown origin) in presence of 10 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50526606(CHEMBL4532948 | US11174264, Compound I-3)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of JAK2 JH1 domain (unknown origin) in presence of 10 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50526606(CHEMBL4532948 | US11174264, Compound I-3)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of JAK3 JH1 domain (unknown origin) in presence of 10 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50526606(CHEMBL4532948 | US11174264, Compound I-3)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) in presence of 10 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed