BDBM50526746 CHEMBL4442153::US10807974, Example 143::US10995088, Example 143::US11608330, Example 143

SMILES Cn1cc(cn1)-c1cc(cc(c1)S(=O)(=O)c1cnc(CN)s1)C(F)(F)F

InChI Key InChIKey=IQIWKCYISJDHLG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50526746   

TargetLysyl oxidase homolog 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526746(CHEMBL4442153 | US10807974, Example 143 | US109950...)
Affinity DataIC50: 259nMAssay Description:Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLysyl oxidase homolog 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526746(CHEMBL4442153 | US10807974, Example 143 | US109950...)
Affinity DataIC50: 310nMAssay Description:10. Incubate for 1 hr at room temp on a plate shaker, protected from light.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
US Patent

TargetLysyl oxidase homolog 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526746(CHEMBL4442153 | US10807974, Example 143 | US109950...)
Affinity DataIC50: 310nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
US Patent

TargetLysyl oxidase homolog 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526746(CHEMBL4442153 | US10807974, Example 143 | US109950...)
Affinity DataIC50: 310nMAssay Description:LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent